A repeatable matrix process
An iPSC-derived, collagen-rich extracellular matrix process aimed at repeatable matrix production.
Research programOrthobiologics · Spine and orthopedic surgery
Bone graft, held to a higher standard.
The biologics behind the fusion, from allograft and synthetics to the patient’s own MSCs.
The PUR portfolio · 12 productsAllograft · Synthetic · MSC recovery
Three families. One portfolio.
Allograft, synthetic, marrow. Every case covered.
Allograft & DBM · 7 products
Synthetic bone graft · 4 products
MSC recovery · 1 system
Allograft
Cortical fiber, DBM putty and cancellous bone in moldable, flowable and strip forms.
- PURbonedough
- PURfiberXP
- PURindux
- PURfuze
- PURfuzePlus
- PURflex
- PURchips
Synthetic
Bioactive glass, bioceramic and collagen matrices in putty, strip and granule form.
- PURactiveOrb
- PURbridge
- PURcrystals
- PURpillars
MSC recovery
A focused system for recovering the patient’s own marrow-derived MSCs at the point of care.
- PURmarrow360
Why it matters
Built for the life after the fusion.
Every graft we ship is going into someone who wants their morning back. That is the standard we hold the portfolio to.
Synthetic bone graft · Featured
PURactiveOrb™
Bioactive glass in orbital form. PURactiveOrb packs bioactive glass into engineered orbs of two sizes, about 80% glass by weight, in a moldable, non-hardening phospholipid putty. The orbs pack densely, present a large bioactive surface for cellular attachment, and leave open spaces between them for new bone to grow into.
Two orb sizes90–180 µm and 355–500 µm: the small orbs fill the gaps between the large ones
~80% glass by weightAbout 1.5 g of bioactive glass in every cc, and the surface area to match
Carrier that steps asideNatural phospholipid, resorbed by local tissue, leaving glass against host bone
Shape it onceMoldable, non-hardening, resists irrigation · 2.5, 5 and 10 cc
Allograft · Featured
PURbonedough™
PURbonedough is 100% human cortical bone, cut into short fibers that interlock when you hydrate them into a dough that holds together, packs where you put it and stays put under irrigation. Nothing in the jar but bone, and every lot tested for osteoinductive potential before it ships.
100% bone, 0% carrierCortical fibers and nothing else in the jar
Hydrate it your waySaline, blood, marrow aspirate or PRP, at your discretion
Every lot testedOsteoinductive potential verified by an independent lab after sterilization, before release
Ready on the shelfRoom-temperature storage, five-year shelf life, 1 to 10 cc jars
The PUR standard
Tested, sourced and sterilized to our standard, not the minimum.
Accreditation and sterility assurance are where every tissue supplier starts. These are the steps beyond that, learned from decades in the field.
13years in orthobiologics
20+years of surgical experience per founder
1000sof surgeries supported
- Donor selection, earned over twenty years
Donor source quality and selection judgment built case by case, not read from a spec sheet.
- Osteoinductivity verified on every lot
Allograft DBM lots are tested for osteoinductive potential before release, not sampled.
- Sterility that preserves biology
Processing designed to deliver a sterile graft without degrading the activity surgeons are relying on.
- Redundant donor sourcing
Multiple qualified tissue sources so supply does not dictate the surgeon's choice of graft.
The complete portfolio
Twelve products. One standard.
PURactiveOrb · MIS delivery
Your graft. Your approach.
PURactiveOrb is available with a minimally invasive delivery option: a trigger-fed instrument and cannula that place putty through a small access corridor.
Company
Focused on biologics. Built around surgeons.
PUR Biologics is a commercial-stage orthobiologics company based in Irvine, California. For thirteen years we have brought allograft, synthetic graft and MSC-recovery products to spine and orthopedic surgeons through a focused portfolio and direct relationships with the people who use it.
We work with surgeons, hospitals and surgery centers, and distribution partners across the United States.
Pipeline
Beyond the portfolio.
Development platformPorous sphere-and-mesh graft
A 510(k)-cleared HA/TCP sphere platform in a mesh format for posterolateral spine graft extension, moving through manufacturing transfer.
Intellectual propertyInternational patent portfolio
Granted patents and applications spanning extracellular matrix manufacturing and regenerative cell-activation technologies.
Research programsECM, cartilage, immune activation
Three research directions exploring how matrices and defined chemistry can inform future biologic technologies.
Contact
Talk to the people behind the portfolio.
Product literature, current instructions for use, ordering, or a conversation about distribution. Our team answers directly.
Home / Products
Products
Purpose in every form.
Twelve products across three families: allograft, synthetics and MSC recovery.
Literature & ordering
Need product literature or the current IFU?
Synthetic bone graft
PURactiveOrb™
Bioactive glass in orbital form. Engineered orbs of two sizes, about 80% glass by weight, in a resorbable phospholipid carrier: moldable, non-hardening, resists irrigation, and ready through a 9 mm cannula.
2.5 cc5 cc10 ccMIS delivery option
Material & handling
Engineered down to the orb.
A material with history. A form without compromise.
Bioactive glass is among the most studied synthetic graft materials in orthopedics. Conventional putties use it as crushed, irregular particles. PURactiveOrb uses orbs: two engineered diameters, 90–180 µm and 355–500 µm, blended in a fixed ratio. The smaller orbs fill the spaces between the larger ones, so the putty packs more glass into the defect and presents a consistent, high surface area to surrounding bone, with interconnected spaces between the orbs for cells and vessels to move into.
That surface is where the material does its work. Bioactive glass forms a calcium phosphate layer at its surface after implantation, and in the orbital form every orb presents that surface for cellular attachment. The result is a putty that is about 80% bioactive glass by weight, roughly 1.5 grams of glass in every cc, bound by a natural phospholipid carrier. After placement the carrier is resorbed and the glass remains in direct contact with host bone.
In a preclinical rabbit defect model, new bone formed directly on the orb surfaces and in the spaces between them, with bone present throughout the implant area at six weeks.1
Supplied in an open-bore syringe sealed within two foil pouches, in 2.5, 5 and 10 cc volumes. No hydration step.
- MoldableShape it in your fingers, contour it to the defect, place it.
- Non-hardeningStays workable and does not set in situ. Not intended to provide structural support.
- Resists irrigationStays where you put it under irrigation, as described in the instructions for use.
- Ready when you areOpen-bore syringe, double foil pouch, single patient use. Open it and go.
1 Preclinical animal study, data on file. Results in animal models do not necessarily predict clinical performance in humans.
MIS delivery option
Your graft. Your approach.
A trigger-fed instrument and cannula place PURactiveOrb through a minimally invasive corridor in controlled increments.
≈0.2 ccper trigger pull
9 mmcannula
Product information
Indications & safety.
Intended use
PURactiveOrb Putty is indicated for bony voids or gaps that are not intrinsic to the stability of the bony structure. It is indicated as a bone void filler in the extremities and pelvis, and as a bone graft extender in the posterolateral spine.
For posterolateral fusion, PURactiveOrb Putty must be mixed with autograft in a 1:1 ratio.
This summary does not replace the complete instructions for use, including contraindications, warnings, precautions and directions.
Handling
Do not add fluid directly to the putty, including blood or saline. This may negatively affect handling and cohesiveness. Refer to the current IFU for preparation and use.
Structural support and single use
The product does not possess sufficient mechanical strength to solely support defect reduction. Appropriate stabilization is required. The product is for single-patient, single use only.
Allograft & DBM
PURbonedough™
100% human cortical bone in a dough that holds together, packs where you put it and stays put under irrigation. Nothing in the jar but bone.
1 cc2.5 cc5 cc10 cc
Material & form
Bone, and only bone.
Cortical fibers that interlock
PURbonedough is made from 100% human cortical bone, processed into short fibers. There is no extrinsic carrier: no collagen, no gelatin, no synthetic binder. When the fibers are hydrated they interlock into a cohesive dough, so the graft handles like a putty while every gram of it is bone.
Supplied dry in a jar, stored at room temperature, with a five-year shelf life from the date of packaging.
- 100% cortical boneNo carrier of any kind. What you place is bone matrix and nothing else.
- Dough handlingPacks into the defect, holds its shape and stays put under irrigation.
- Room temperatureNo cold chain. Shelf life of five years from packaging.
- 1 to 10 ccFour jar sizes for everything from a small void to a multilevel posterolateral bed.
Hydration & handling
Hydrate it your way.
PURbonedough is hydrated in the field with the fluid the surgeon chooses: saline, whole blood, bone marrow aspirate or platelet-rich plasma, at the physician’s discretion. The fibers take up the fluid and bind into a dough that can be shaped, packed and held in place.
Saline or bloodStandard hydration for a cohesive, moldable graft
Marrow aspiratePair with PURmarrow360 to deliver the patient’s own MSCs in the graft
PRPPlatelet-rich plasma, where the surgeon prefers it
Resists irrigationHolds together under irrigation once placed, per the IFU
Every lot tested
Osteoinductive potential, verified lot by lot.
Demineralized bone is only as good as the lot in your hand. Every lot of PURbonedough is tested for osteoinductive potential by an independent laboratory after sterilization and before release. Not sampled. Not inferred from a sister lot. Tested.
After sterilizationTested on the finished, sterile product, not the raw material
Independent labVerification is done outside the processor
Before releaseA lot that does not pass does not ship
Donor disciplineEligibility reviewed by a licensed medical director against FDA and AATB standards
Product information
Indications & safety.
Intended use
PURbonedough is a human tissue allograft intended for homologous use in the repair, replacement or reconstruction of surgically created or traumatic skeletal defects.
This summary does not replace the complete instructions for use, including contraindications, warnings, precautions and directions. Human tissue is regulated under 21 CFR Part 1271.
Handling and hydration
Hydrate per the instructions for use with the fluid selected by the physician. Do not re-sterilize. Single patient, single use.
Storage
Store at ambient temperature, 15–30 °C (59–86 °F). Do not use after the expiration date on the label.
Home / Pipeline
Pipeline
Beyond the portfolio. Into what's next.
Distinctive materials, protected technologies and a research program built around regenerative medicine.
Development platform
A different architecture for graft extension.
A synthetic graft platform of porous HA/TCP spheres contained in a mesh format, developed for posterolateral spine graft extension. The platform is 510(k)-cleared; manufacturing transfer and shelf-life work are the next milestones on the path to commercial release.
This platform is distinct from PURactiveOrb Putty, our bioactive glass product.
HA/TCPHydroxyapatite / tricalcium phosphate
Porous spheresContained in a mesh format
510(k)-clearedPosterolateral spine graft extension
Next milestonesManufacturing transfer · shelf-life studies
Intellectual property
Multiple international patents and applications.
PUR's intellectual-property portfolio spans extracellular matrix manufacturing and regenerative cell-activation technologies, with patent work extending into bone and cartilage programs. These technologies form the foundation for a research pipeline that reaches beyond today's commercial catalog.
Research directions
Three paths. A regenerative focus.
Extending the field
Patent work spanning cartilage regeneration, alongside PUR's broader matrix and bone-focused programs.
Patent & research focusDefined chemistry, cellular potential
A defined molecular composition intended to activate bone-marrow-derived immune cells, with bone regeneration as an initial application.
Research programResearch programs describe development objectives, not established clinical outcomes or commercially available treatments. The sphere platform's clearance does not apply to the ECM, cartilage or immune-activation programs.
Scientific & strategic inquiries