A repeatable matrix process
An iPSC-derived, collagen-rich extracellular matrix process aimed at repeatable matrix production.
Research programOrthobiologics · Spine and orthopedic surgery
Bone graft, held to a higher standard.
The authority and future in ortho & spinal biologics.
Allograft, synthetic and marrow-collection products for fusion, from a team that has spent twenty years in the operating room with surgeons.
The PUR portfolio · 12 productsAllograft · Synthetic · Marrow collection
Three families. One portfolio.
Allograft, synthetic, marrow. Every case covered.
Allograft & DBM · 7 products
Synthetic bone graft · 4 products
Marrow collection · 1 system
Allograft
Cortical fiber, DBM putty and cancellous bone in moldable, flowable and strip forms.
- PURbonedough
- PURfiberXP
- PURindux
- PURfuze
- PURfuzePlus
- PURflex
- PURchips
Synthetic
Bioactive glass, bioceramic and collagen matrices chosen on their own merit, not as a fallback.
- PURactiveOrb
- PURbridge
- PURcrystals
- PURpillars
Marrow collection
A focused system for recovering bone marrow aspirate at the point of care.
- PURmarrow360
Why it matters
Life back in action.
Every graft we ship is going into someone who wants their morning back. That is the standard we hold the portfolio to.
Synthetic bone graft · Featured
PURactiveOrb™
Bioactive glass, finally in a form that behaves in the hand. PURactiveOrb packs 45S5 bioactive glass into engineered spheres of two sizes, about 80% glass by weight, in a moldable, non-hardening phospholipid putty. Shape it, place it, and let the carrier get out of the way.
Two sphere sizes90–180 µm and 355–500 µm, blended in a fixed ratio for dense packing
~80% glass by weightAbout 1.5 g of 45S5 bioactive glass in every cc
Carrier that steps asideNatural phospholipid, resorbed by local tissue, leaving glass against host bone
Shape it onceMoldable, non-hardening, resists irrigation · 2.5, 5 and 10 cc
Allograft · Featured
PURbonedough™
The allograft surgeons reach for by feel. PURbonedough is 100% human cortical bone, cut into short fibers that interlock when you hydrate them into a dough that holds together, packs where you put it and stays put under irrigation. Nothing in the jar but bone, and every lot tested for osteoinductive potential before it ships.
100% bone, 0% carrierCortical fibers and nothing else in the jar
Hydrate it your waySaline, blood, marrow aspirate or PRP, at your discretion
Every lot testedOsteoinductive potential verified by an independent lab after sterilization, before release
Ready on the shelfRoom-temperature storage, five-year shelf life, 1 to 10 cc jars
The PUR standard
Discipline you can feel in the graft.
Accreditation and sterility assurance are the entry ticket in this market. What separates a graft is the judgment behind it.
13years in orthobiologics
20+years of surgical experience per founder
1000sof surgeries supported
- Donor selection, earned over twenty years
Donor source quality and selection judgment built case by case, not read from a spec sheet.
- Osteoinductivity verified on every lot
Allograft DBM lots are tested for osteoinductive potential before release, not sampled.
- Sterility that preserves biology
Processing designed to deliver a sterile graft without degrading the activity surgeons are relying on.
- Redundant donor sourcing
Multiple qualified tissue sources so supply does not dictate the surgeon's choice of graft.
The complete portfolio
Twelve products. One standard.
PURactiveOrb · MIS delivery
Your graft. Your approach.
PURactiveOrb is available with a minimally invasive delivery option: a trigger-fed instrument and cannula that place putty through a small access corridor.
Company
Focused on biologics. Built around surgeons.
PUR Biologics is a commercial-stage orthobiologics company based in Irvine, California. For thirteen years we have brought allograft, synthetic graft and marrow-collection products to spine and orthopedic surgeons through a focused portfolio and direct relationships with the people who use it.
We work with surgeons, hospitals and surgery centers, and distribution partners across the United States.
Pipeline
Beyond the portfolio.
Development platformPorous sphere-and-mesh graft
A 510(k)-cleared HA/TCP sphere platform in a mesh format for posterolateral spine graft extension, moving through manufacturing transfer.
Intellectual propertyInternational patent portfolio
Granted patents and applications spanning extracellular matrix manufacturing and regenerative cell-activation technologies.
Research programsECM, cartilage, immune activation
Three research directions exploring how matrices and defined chemistry can inform future biologic technologies.
Contact
Talk to the people behind the portfolio.
Product literature, current instructions for use, ordering, or a conversation about distribution. Our team answers directly.
Home / Products
Products
Purpose in every form.
Twelve products across three families. Each one is here because it does a specific job in the fusion better than the alternative.
Literature & ordering
Need product literature or the current IFU?
Synthetic bone graft
PURactiveOrb™
The bioactive glass putty surgeons can shape. 45S5 glass in engineered spheres, about 80% glass by weight, in a resorbable phospholipid carrier: moldable, non-hardening, resists irrigation, and ready through a 9 mm cannula.
2.5 cc5 cc10 ccMIS delivery option
Material & handling
Engineered down to the sphere.
A material with history. A form without compromise.
45S5 bioactive glass is among the most studied synthetic graft materials in orthopedics. Conventional putties use it as crushed, irregular particles. PURactiveOrb uses spheres: two engineered diameters, 90–180 µm and 355–500 µm, blended in a fixed ratio so the particles pack densely and present a consistent surface to surrounding bone.
The result is a putty that is about 80% bioactive glass by weight, roughly 1.5 grams of glass in every cc, bound by a natural phospholipid carrier that gives it its feel. After placement the carrier is resorbed and the glass remains in direct contact with host bone.
In a preclinical rabbit defect model, new bone formed directly on the sphere surfaces and in the spaces between them, with bone present throughout the implant area at six weeks.1
Supplied in an open-bore syringe sealed within two foil pouches, in 2.5, 5 and 10 cc volumes. No hydration step.
- MoldableShape it in your fingers, contour it to the defect, place it.
- Non-hardeningStays workable and does not set in situ. Not intended to provide structural support.
- Resists irrigationStays where you put it under irrigation, as described in the instructions for use.
- Ready when you areOpen-bore syringe, double foil pouch, single patient use. Open it and go.
1 Preclinical animal study, data on file. Results in animal models do not necessarily predict clinical performance in humans.
MIS delivery option
Your graft. Your approach.
A trigger-fed instrument and cannula place PURactiveOrb through a minimally invasive corridor in controlled increments.
≈0.2 ccper trigger pull
9 mmcannula
Product information
Indications & safety.
Intended use
PURactiveOrb Putty is indicated for bony voids or gaps that are not intrinsic to the stability of the bony structure. It is indicated as a bone void filler in the extremities and pelvis, and as a bone graft extender in the posterolateral spine.
For posterolateral fusion, PURactiveOrb Putty must be mixed with autograft in a 1:1 ratio.
This summary does not replace the complete instructions for use, including contraindications, warnings, precautions and directions.
Handling
Do not add fluid directly to the putty, including blood or saline. This may negatively affect handling and cohesiveness. Refer to the current IFU for preparation and use.
Structural support and single use
The product does not possess sufficient mechanical strength to solely support defect reduction. Appropriate stabilization is required. The product is for single-patient, single use only.
Home / Pipeline
Pipeline
Beyond the portfolio. Into what's next.
Distinctive materials, protected technologies and a research program built around regenerative medicine.
Development platform
A different architecture for graft extension.
A synthetic graft platform of porous HA/TCP spheres contained in a mesh format, developed for posterolateral spine graft extension. The platform is 510(k)-cleared; manufacturing transfer and shelf-life work are the next milestones on the path to commercial release.
This platform is distinct from PURactiveOrb Putty, our bioactive glass product.
HA/TCPHydroxyapatite / tricalcium phosphate
Porous spheresContained in a mesh format
510(k)-clearedPosterolateral spine graft extension
Next milestonesManufacturing transfer · shelf-life studies
Intellectual property
Multiple international patents and applications.
PUR's intellectual-property portfolio spans extracellular matrix manufacturing and regenerative cell-activation technologies, with patent work extending into bone and cartilage programs. These technologies form the foundation for a research pipeline that reaches beyond today's commercial catalog.
Research directions
Three paths. A regenerative focus.
Extending the field
Patent work spanning cartilage regeneration, alongside PUR's broader matrix and bone-focused programs.
Patent & research focusDefined chemistry, cellular potential
A defined molecular composition intended to activate bone-marrow-derived immune cells, with bone regeneration as an initial application.
Research programResearch programs describe development objectives, not established clinical outcomes or commercially available treatments. The sphere platform's clearance does not apply to the ECM, cartilage or immune-activation programs.
Scientific & strategic inquiries